The story begins before Gandhi became widely known as the Mahatma, focusing on his childhood struggles with fear, temptation, self-doubt, and failure. His experiences abroad, particularly in South Africa, become important to the development of the ideas and methods that would later define his approach to political action.

After returning to India, Gandhi becomes increasingly involved in the country's freedom struggle. The comic follows significant episodes from his public life, including Champaran, the Salt March, interactions with British authorities, and the Quit India movement.

The Life of Mahatma Gandhi: Classic Indian Stories also covers the difficult period surrounding Partition and Gandhi's final efforts to address communal violence. Rather than presenting only a simplified heroic image, the narrative focuses on the struggles, decisions, sacrifices, and convictions behind the historical figure.